Base pairs are at the heart of molecular biology information. Definition of «Base Pair». "Chapter 10. Get XML access to fix the meaning of your metadata. Hence, the number of total base pairs is equal to the number of nucleotides in one of the strands (with the exception of non-coding single-stranded regions of telomeres). ○ Anagrams English thesaurus is mainly derived from The Integral Dictionary (TID). (2012). Some DNA- or RNA-binding enzymes can recognize specific base pairing patterns that identify particular regulatory regions of genes. Springer. Base pairing results in the formation of a double helix between complementary single-stranded nucleic acid; in DNA, pairing is between adenine and thymine, and between guanine and cytosine. All rights reserved. Give contextual explanation and translation from your sites ! Privacy policy 'All humans have the same genes, in other words, the same basic instructions, but in some people, one DNA, Peterlechner et al., "Formation of silver nanoclusters from a DNA template containing Ag(I)-mediated, By using the proper combination of a very thin capillary, appropriate choice of gel or polymer fill in, and electric field parameters, it is possible to reliably separate new DNA strands of single-base length differences up to around 1,000, In 2014, Floyd Romesberg from the Scripps Research Institute in La Jolla, California, and his colleagues went beyond just imagining such a creature; they synthesized a new, The DNA was divided into three major parts: G-C, With two samples, two distinct peaks were observed, one at 263, Generally, the replicative DNA polymerases have difficulty progressing through distorted DNA, and mismatched purine (Pur):Pur or pyrimidine (Pyr):Pyr, The new kits double sequencing output to 15 gigabases (Gb) by raising the number of sequencing reads (up to 25 million reads) and overall read length (up to 2x300, Through molecular biology studies, from the discovery of the double helix structure of DNA in 1953 (1) to the deciphering of the genetic code in the 1960s, (2-4) researchers revealed that the complementarity of the A-T(U) and G-C. … Molecular Biology of the Gene. Other chemicals, known as DNA intercalators, fit into the gap between adjacent bases on a single strand and induce frameshift mutations by "masquerading" as a base, causing the DNA replication machinery to skip or insert additional nucleotides at the intercalated site. Comparison of Stacked and H-Bonded Base Pairs". Watson JD, Baker TA, Bell SP, Gann A, Levine M, Losick R. (2004). Higher GC content results in higher melting temperatures; it is, therefore, unsurprising that the genomes of extremophile organisms such as Thermus thermophilus are particularly GC-rich. In molecular biology and genetics, the linking between two nitrogenous bases on opposite complementary DNA or certain types of RNA strands that are connected via hydrogen bonds is called a base pair (often abbreviated bp). Purines are complementary only with pyrimidines: pyrimidine-pyrimidine pairings are energetically unfavorable because the molecules are too far apart for hydrogen bonding to be established; purine-purine pairings are energetically unfavorable because the molecules are too close, leading to overlap repulsion. By using our services, you agree to our use of cookies. Tips: browse the semantic fields (see From ideas to words) in two languages to learn more. This is called Chargaff's rule of complementary base pairing. base pairing: The specific complementary hydrogen bonding of nitrogenous bases—purines and pyrimidines—in a double-stranded nucleic acid. Get XML access to reach the best products. ○ Lettris pp. base-pairing: (bās′pâr′ĭng) n. The hydrogen bonding of complementary nitrogenous bases, one purine and one pyrimidine, in DNA and in hybrid molecules joining DNA and RNA. Megger, Dominik A.; Megger, Nicole; Mueller, Jens. This entry is from Wikipedia, the leading user-contributed encyclopedia. A windows (pop-into) of information (full-content of Sensagent) triggered by double-clicking any word on your webpage. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Antonyms for base-pairing. | Each base can only bond with one other, A-T and C-G. Pearson Benjamin Cummings: CSHL Press. ISBN 978-94-007-2171-5. (1997) Theoretical and experimental study of isoguanine and isocytosine: In general, the creation of unnatural base pairs is initiated by designing the molecular structures or modifying the A-T and G-C pairs, based on a certain idea or concept underlying the mechanism of the selective complementarity of the natural, (40,43,44) For the creation of unnatural base pairs, these factors should also be considered, besides the hydrogen-bonding pattern and shape-complementarity of the, For replication studies, the steady-state kinetic parameters ([V.sub.max]/[K.sub.M] or [k.sub.cat]/[K.sub.M]) of cognate and non-cognate, Primer extension and PCR amplification in the presence of all substrates of natural and unnatural bases are more practical assessments of unnatural, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. Alternative DNA Base-Pairing through Metal Coordination". https://medical-dictionary.thefreedictionary.com/base+pairing, Therefore, we further improved the unnatural base pair system to bypass the need for the .amidotriphosphates, while maintaining the high selectivity (more than 99%) of the unnatural. The following DNA sequences illustrate pair double-stranded patterns. Alternate hydrogen bonding patterns, such as the wobble base pair and Hoogsteen base pair, also occur—in particular, in RNA—giving rise to complex and functional tertiary structures. 5 words related to base pair: deoxyribonucleic acid, desoxyribonucleic acid, DNA, nucleotide, base. [1][2][3] A kilobase (kb) is a unit of measurement in molecular biology equal to 1000 base pairs of DNA or RNA. Each square carries a letter. Lettris is a curious tetris-clone game where all the bricks have the same square shape but different content. may be used for base pairs. Detailed Synonyms for base pair in English. Peter Yakovchuk, Ekaterina Protozanova and Maxim D. Frank-Kamenetskii. Appropriate geometrical correspondence of hydrogen bond donors and acceptors allows only the "right" pairs to form stably. Chemical analogs of nucleotides can take the place of proper nucleotides and establish non-canonical base-pairing, leading to errors (mostly point mutations) in DNA replication and DNA transcription. Choose the design that fits your site. The code for attribution links is required. The web service Alexandria is granted from Memodata for the Ebay search. Purine-pyrimidine base pairing of AT or GC results in proper duplex structure. – one of the pairs of chemical bases joined by hydrogen bonds that connect the complementary strands of a DNA molecule or of an RNA molecule that has two strands; the base pairs are adenine with thymine and guanine with cytosine in DNA and adenine with urac, Your free, fast, and simple translation dictionary, WordNet 3.0 Copyright 2006 by Princeton University, one of the pairs of chemical bases joined by hydrogen bonds that connect the complementary strands of a DNA molecule or of an RNA molecule that has two strands; the base pairs are adenine with thymine and guanine with cytosine in DNA and adenine with urac. In RNA, thymine is replaced by uracil (U). Search base pairing and thousands of other words in English definition and synonym dictionary from Reverso. (Note, however, that a GC stacking interaction with the next base pair is geometrically different from a CG interaction.) Metal Ions in Life Sciences. "Nature of Nucleic Acid−Base Stacking: Nonempirical ab Initio and Empirical Potential Characterization of 10 Stacked Base Dimers. pp. In the canonical Watson-Crick DNA base pairing, adenine (A) forms a base pair with thymine (T) and guanine (G) forms a base pair with cytosine (C). ○ Wildcard, crossword disengage fall natural depression stand still hop out. See if you can get into the grid Hall of Fame ! Change the target language to find translations. The GU pairing, with two hydrogen bonds, does occur fairly often in RNA (see wobble base pair). DNA with high GC-content is more stable than DNA with low GC-content, but, contrary to popular belief, the hydrogen bonds do not stabilize the DNA significantly, and stabilization is mainly due to stacking interactions.[5]. The Centimorgan is also often used to imply distance along a chromosome, but the number of base pairs it corresponds to varies widely. | Last modifications, Copyright © 2012 sensagent Corporation: Online Encyclopedia, Thesaurus, Dictionary definitions and more. Contact Us Synonyms for base-pairing in Free Thesaurus. Copy the code below and paste it where you want the visualization of this word to be shown on your page: Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Genetics, pollution severe asthma symptoms: Study, How to Make Gene-Editing CRISPR Work Even Better, Comparative Analysis of miRNA-Target Prediction Algorithms with Experimentally Positive Data in C. elegans and R. norvegicus Genomes, Corrigendum to "Formation of Silver Nanoclusters from a DNA Template Containing Ag(I)-Mediated Base Pairs", Back to basics: Sanger sequencing and its applications, On the Dimers Stability of Allicin and Its Derivatives Interacting with AT, GC, and DNA Bridge: DFT Study, Screening for calreticulin mutations in a cohort of patients suspected of having a myeloproliferative neoplasm, Ancestral humans had more DNA: genetic cuts and copies show evolutionary kinships, Structure Modeling of Small Subunit Ribosomal RNA (SSU rRNA) of Copper Resistant Ciliates, Effects of stability of base pairs containing an oxazolone on DNA elongation, Illumina introduces new reagent kits for MiSeq sequencing system, Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma, basal body temperature method of family planning. ), http://sandwalk.blogspot.com/2011/03/how-big-is-human-genome.html, http://www.strategicgenomics.com/Genome/index.htm, "Finishing the euchromatic sequence of the human genome", http://www.nature.com/nature/journal/v431/n7011/full/nature03001.html.
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